Sweet fruit discovered to have the ability to prevent colorectal cancer

The good news is that new research shows that mangoes have the ability to fight colorectal cancer, according to the medical website News Medical.

Research recently published in the scientific journal Scientific Reports , has found that treatment with Mangiferin (MF), a natural compound found in mangoes, reduced the size and severity of colon adenomas and adenocarcinomas. Furthermore, it also reduced the number of abnormal polyps in the colon.

Colorectal cancer is the third most common cancer in the world.

An international study conducted jointly by scientists from Al-Ahliyya University Amman (Jordan), University of Malaya (Malaysia), Jeddah University and Umm Al-Qura University (Saudi Arabia), Erbil Polytechnic University and Cihan-Erbil University (Iraq) evaluated the anti-cancer effects of MF in mango on abnormal tumors in the colon and rectal mucosa in cancer-induced mice.

Dysplasias form before colorectal polyps and are one of the earliest changes in the colon that can lead to cancer.

A total of 15 mice were induced to develop cancer by injecting the carcinogen azoxymethane (AOM). The researchers observed that after AOM injection, all mice developed multiple colon adenomas and adenocarcinomas with significant visceral metastasis, especially in the intestinal lymph nodes.

These mice were divided into 3 groups: Group 1 as control, group 2 received low dose of MF and group 3 received high dose of MF.

MF in mangoes has the ability to prevent colon cancer.

The results showed that MF treatment reduced the size and severity of colon adenomas and adenocarcinomas. Furthermore, mice treated with MF had fewer total abnormal tumors in the colon than the control group. Notably, both low and high doses of MF were safe and had no side effects, according to News Medical .

The researchers concluded: MF may be used as an alternative intervention for the treatment of colorectal cancer.

Several studies have also documented the antioxidant, antifungal, analgesic, antibacterial, antidiabetic, anti-inflammatory, and cardioprotective properties of MF.

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