Lithium opens new hope for Alzheimer's treatment

Experimental studies in mice showed that lithium orotate supplementation prevented the formation of two proteins in the brain that are characteristic of Alzheimer's disease, neuroinflammation and demyelination – the entire mechanism that leads to cognitive decline.

A research team from Harvard Medical School (USA) discovered that the natural element lithium may be related to the pathogenesis and treatment of Alzheimer's - a degenerative neurological disease that affects more than 35 million people worldwide , including nearly 1 million French people, characterized by the formation and accumulation of two types of proteins in the brain - plaques (amyloid-beta) and tangles (tau), causing damage to nerve cells.

According to a VNA reporter in Paris, research published in the journal Nature shows that lithium concentrations in the brain tissue of Alzheimer's patients are significantly reduced.

When mice were fed a lithium-deficient diet, amyloid plaques increased; conversely, supplementation with a new salt, lithium orotate, prevented amyloid formation, limiting tau protein modification, neuroinflammation, and myelin degeneration—that is, the entire mechanism leading to cognitive decline. The mice even recovered their memory.

Compared to lithium carbonate used in previous trials, lithium orotate is superior in that it is not “trapped” by amyloid plaques. Thanks to that, scientists hope to be able to shorten the research process and start testing on early-stage Alzheimer’s patients in the next 4–5 years.

However, experts warn against taking lithium orotate supplements on your own because a safe dose in the elderly has not been determined.

They also emphasize that Alzheimer's is a multifactorial disease, so lithium is likely to be only one part of a combination treatment regimen.

Currently, there are about 150 other compounds being tested worldwide, opening up new hope, but treating Alzheimer's disease is still extremely complicated./.

(TTXVN/Vietnam+)

Source: https://www.vietnamplus.vn/nguyen-to-lithium-mo-hy-vong-moi-cho-dieu-tri-benh-alzheimer-post1056811.vnp